An overdose of nicotinic acid: symptoms, treatment
Nicotinic acid (Niacin) is a biologically active substance that enters the human body with food. If cells and tissues are deficient vitamin, it disrupted all vital systems, reduced immunity, deteriorating appearance. To replenish the used synthesized Niacin vitamin PP in the form of tablets, solution for parenteral administration. Overdose of Niacin can be caused by failure to comply with medical recommendations and improper storage.
Characteristic features of the drug
Niacin belongs to the vitamins, who are actively involved in redox processes. With the participation of Niacin in the human body, the synthesis of enzymatic compounds that regulates the metabolism of carbohydrates and lipids in tissues.
An overdose of vitamin PP is often diagnosed in people who are trying to lose weight. The ability of nicotinic acid to speed up the metabolic processes used by women for weight loss. Usually, this leads to poisoning, painful headaches, and severe depression.
The solid form of Niacin is a white crystalline powder, odourless, faint sour taste. Poorly bred in cold water, when boiling almost immediately goes into solution. Nicotinic acid is found in many foods, such:
- rye bread, buckwheat, bean;
- meat, kidney, liver;
- mushrooms, beets, pineapple, mango.
Vitamin retains its properties after boiling and freezing. Artificial nicotinic acid was obtained almost 200 years ago. This was achieved through the oxidation of nicotine chromic acid.
Pharmacological action of nicotinic acid
Often overdose biologically active substance is due to the wishes of patients as quickly as possible to achieve maximum therapeutic effect. Nicotinic acid has the ability to accumulate in tissues, so it is used exclusively for a course of treatment. After conducting laboratory tests, the doctor will choose an individual and determine the dose required for therapy, the duration of use of tablets.
Despite the fact that the drug is classified as a vitamin, nicotinic acid intoxication leads to severe for the body consequences. You should store the medicine out of reach of small children, because they are always interesting neat bottles of pills.
In pharmacology and medicine nicotinic acid is used not only for the treatment of pathologies, but also for the prevention of relapses of chronic diseases, the prevention of beriberi. Niacin has a positive effect on the human body:
- Normalizes metabolism of fats and carbohydrates.
- Involved in the transmission of nerve impulses.
- Improves the metabolism in cells and tissues.
- Restores blood circulation in damaged areas of the internal organs and brain.
- Lowers blood pressure, dilates the blood vessels.
- Normalizes oxidation processes and oxygen exchange.
The ability of nicotinic acid to accelerate metabolism and is rapidly excreted from the body is used for the treatment of poisoning poisons or toxic compounds. Solutions of vitamin PP is used for conducting detoxification therapy overdose of narcotic drugs and ethyl alcohol.
Rational use of vitamin PP
Overdose of Niacin develops under the misuse of drugs. Cases of acute poisoning with nicotinic acid, which have been developed for external use of the drug for parenteral administration. Young women who suffer from heavy hair loss in the postpartum period, the solution rubbed undiluted into the scalp at night. Usually in the morning they will find an unexpected effect:
- painful headache;
- nausea, vomiting;
- weakness, unsteadiness of gait due to the sharp pressure drop;
- burned itchy scalp.
Hair loss in nursing mothers due to resulting hormonal imbalance. This state is temporary – it is impossible to remove by conventional vitamins, especially at such an unusual use.
Nicotinic acid is not used on an empty stomach. In the absence of food, there is a risk of overdose, since the vitamin is characterized by a high degree of absorption. In addition to the symptoms of intoxication, the risk of irritation and ulceration of the mucous membrane of the gastrointestinal tract.
The drug is used in drug therapy of the following diseases:
- Osteochondrosis of the cervical and thoracic spine, including as a solution for electrophoresis.
- The stroke of ischemic etiology.
- Pellagra (pathology deficiency of nicotinic acid).
- Poor circulation in the legs, sores.
- Diseases of the liver.
- Glucose intolerant.
With prophylactic purposes nicotinic acid used to correct twilight vision, when treating hemorrhoids. Pharmacological drug improves memory, promotes the production of pepsin, enzymes andgastric juice with hypoacid gastritis.
Chronic overdose of nicotinic acid in long-term care can be prevented. To do this, the doctor prescribes a periodic change of biochemical blood and urine tests. If biological samples have exceeded the level of vitamin PP and its degradation products, pill reduces or decreases the frequency of their use.
The clinical picture of overdose
When an overdose is particularly dangerous property of a medicine to drastically reduce the pressure. Hypotensive, this condition will cause dizziness, fainting, deep coma, which can result in the death of a person. To dangerous symptoms of poisoning also include:
- a significant rise in temperature, tides of blood to the face and upper body;
- vomiting, nausea, decreased bowel motility;
- allergic reactions due to the decrease in the functional activity of the liver;
- excessive sweating, migraines, emotional instability;
- decrease in tactile, muscular, tendon reflexes;
- difficulties with swallowing, dryness of the mucous membranes;
- the vagueness of the question.
An overdose of vitamin PP can occur when it is used as the main ingredient of masks for rejuvenation. The ability of nicotinic acid to provoke a rush of blood to the face is used by women for the updates of the upper layer of the epidermis. Niacin penetrates the blood stream, accumulate in tissues and cause toxicity.
Nicotinic acid and its derivatives in significant concentrations can have a depressive effect on the Central nervous system. First, a person increases physical activity, lift forces, and then develops a condition similar to drug (confusion, drowsiness, apathy).
After the first signs of overdose should seek medical advice. Antidote nicotinic acid does not exist, so treatment will focus on eliminating the symptoms of poisoning. How to help the victim:
- Lay on its side, to reassure.
- Drink strong sweet tea, to give any adsorbents or sorbents.
To clean the stomach in case of intoxication nicotinic acid makes sense if the pill has occurred recently. Niacin is rapidly absorbed by the tissues of the internal organs and is also rapidly excreted from the body.